Is pazopanib toxic to the liver? from indian generic price's blog

Yes, pazopanib (Votrient) can be toxic to the liver. Liver toxicity is one of the known side effects of the drug, and it can manifest as an increase in liver enzymes (such as AST, ALT, and bilirubin) or, in more severe cases, as liver damage or hepatotoxicity.

Liver-related side effects of pazopanib:

Increased liver enzymes:

Pazopanib can cause an increase in liver enzymes, which is often detected during routine blood tests. These changes are usually temporary and may not cause symptoms, but they can indicate liver stress or damage and Pazopanib Cost Philippines.

Hepatotoxicity:

In some cases, pazopanib can cause more damage to the liver, causing symptoms such as jaundice (yellowing of the skin or eyes), dark urine, abdominal pain, nausea, vomiting, and fatigue. Severe liver toxicity can be life threatening and may require stopping the drug.

Liver function monitoring:

Because of the potential for liver toxicity, patients on pazopanib are monitored regularly with blood tests to assess liver function, especially during the early stages of treatment or when the dose is adjusted. Monitoring includes checking liver enzymes (AST, ALT, alkaline phosphatase) and bilirubin levels.

Risk factors:

Patients with pre-existing liver conditions or previously diagnosed liver disease may be at higher risk for liver toxicity. It is important for patients to inform their healthcare provider of any liver-related problems before starting treatment with pazopanib.

Recommendations for management:

Dose adjustment or discontinuation: If significant increases in liver enzymes or symptoms of liver toxicity are found, the healthcare provider may adjust the dose of pazopanib or temporarily stop treatment. In severe cases, the drug may need to be permanently discontinued.

Close monitoring: Regular liver function tests are necessary to detect any possible liver damage in treatment.

Conclusion:

Yes, pazopanib can be toxic to the liver, and liver function should be carefully monitored during treatment. Most cases of liver toxicity are manageable, but in some cases, if severe liver damage occurs, dose adjustments or discontinuation may be necessary. Always follow the guidance of your healthcare provider to minimize the risk and ensure safe use of the drug.

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