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Yes, pazopanib (Votrient) can be toxic to the liver. Liver toxicity is one of the known side effects of the drug, and it can manifest as an increase in liver enzymes (such as AST, ALT, and bilirubin) or, in more severe cases, as liver damage or hepatotoxicity. Liver-related side effects of pazopanib: Increased liver enzymes: Pazopanib can cause an increase in liver enzymes, which is often detected during routine blood tests. These changes are usually temporary and may not cause symptoms, but they can indicate liver stress or damag... more