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Nasolabial folds are wrinkles that occur on the face, typically around the mouth and nose. They are caused by a loss of collagen and elastin in the skin, which leads to sagging skin and a loss of youthful volume. This can happen due to a variety of factors, including aging, sun damage, smoking, and weight loss.   What are nasolabial folds? Sagging nasolabial folds(also known as "jowls") are folds of skin that run down the side of your face. They can sag because they become loose and lose their elasticity over time... more