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DNA modifying enzymes play a key role in the development of various medical and industrial applications. An important tool for analyzing the activity and specificity of these enzymes is clustering analysis. Cluster analysis is a bioinformatics technique involving the grouping of related sequences based on similarity. Cluster analysis allows researchers to group similar enzyme sequences and identify conserved patterns that are critical to enzyme function. This information can be used to develop more efficient enzymes or improve existi... more

A team led by scientists at the Scripps Research Institute and the University of Amsterdam has achieved an important goal in virology: mapping key proteins that attach to the surface of the hepatitis C virus (HCV) and enable it to enter host cells at high resolution.   The findings, published recently in Science, detail the key vulnerable sites of the virus, which can now be effectively targeted by vaccines.   Dr. Gabriel Lander, a professor in the Department of Integrated Structural and Computational Biol... more