Researchers have indicated that when people consume a natural dietary
supplement called nicotinamide riboside (NR) daily, it mimics caloric
restriction (CR), kick-starting the same key chemical pathways
responsible for its health benefits.Supplementation also tends to
improve blood pressure and arterial health, particularly in those with
mild hypertension, the study found.
Nicotinamide Riboside Chloride powder
“This was the first ever study to give this novel compound to humans
over a period of time,” said senior author Doug Seals, a Professor and
researcher in the Department of Integrative Physiology at the University
of Colorado Boulder. “We found that it is well tolerated and appears to
activate some of the same key biological pathways that calorie
restriction does.”Dr Seal and lead author Chris Martens included 24 lean
and healthy men and women ages 55 to 79 from the Boulder area.Half were
given a placebo for six weeks, then took a 500 mg twice-daily dose of
nicotinamide riboside (NR) chloride (NIAGEN). The other half took NR for
the first six weeks, followed by placebo.The researchers took blood
samples and other physiological measurements at the end of each
treatment period. Participants reported no serious adverse effects.
The researchers found that 1,000 mg daily of NR boosted levels of
another compound called nicotinamide adenine dinucleotide (NAD+) by 60
percent. NAD+ is required for activation of enzymes called sirtuins,
which are largely credited with the beneficial effects of calorie
restriction. It’s involved in a host of metabolic actions throughout the
body, but it tends to decline with age.
Research suggests that as an evolutionary survival mechanism, the body
conserves NAD+ when subjected to calorie restriction. But only recently
have scientists begun to explore the idea of supplementing with
so-called “NAD+-precursors” like NR to promote healthy ageing.“The idea
is that by supplementing older adults with NR, we are not only restoring
something that is lost with ageing (NAD+), but we could potentially be
ramping up the activity of enzymes responsible for helping protect our
bodies from stress,” Martens said.
The new study also found that in 13 participants with elevated blood
pressure or stage 1 hypertension (120-139/80-89 mmHg), systolic blood
pressure was about 10 points lower after supplementation. A drop of that
magnitude could translate to a 25 percent reduction in heart attack
risk.“If this magnitude of systolic blood pressure reduction with NR
supplementation is confirmed in a larger clinical trial, such an effect
could have broad biomedical implications,” the authors note.
Ultimately, the authors say, such CR-mimicking compounds could provide
an additional option–alongside the dietary changes and exercise
currently recommended–for people whose blood pressure is not yet high
enough to warrant medication but who are still at risk for a heart
attack.
“We are not able to make any definitive claims that this compound is
safe or going to be effective for specific segments of the population,”
said Dr Martens, now an Assistant Professor at the University of
Delaware. “What this paper provides us with is a really good stepping
stone for future work.”
Dr Martens and Dr Seal have applied for a grant to conduct a larger
clinical trial looking specifically at the impact of NR supplementation
on blood pressure and arterial health. Dr Martens is also launching a
separate trial looking at the impact NR has on older adults with mild
cognitive impairment, a precursor to Alzheimer’s disease.
Nefiracetam (chemical name
N-(2,6-dimethylphenyl)-2-(2-oxopyrrolidin-1-yl)acetamide) is one of the
more modern racetams and is purported to have much wider effects on
brain activities than the first generation of racetams, and is
considerably more potent. Unlike piracetam, it is fat soluble.
Nefiracetam powder
Due to its wide ranging uses, nefiracetamis considered to be a second
generation racetam. Due to its far ranging effects and possible uses,
like pramiracetam it has become a popular supplement for sufferers of
Alzheimer's disease and dementia.
The technical term for smart drugs is nootropics, which are a group of
health supplements which are purported to increase cognitive ability,
intelligence, memory, and general brain function.
As an analogue to piracetam, it is considered that nefiracetam is
virtually non-toxic, non addictive, has very few side effects, and
enhances verbal memory. Nonetheless, unlike piracetam there have been
fewer clinical trials and research into the affects of nefiracetam,
however it is widely considered to be considerably more potent than
piracetam, and users of nefiracetam generally report that it improves
memory, alertness, and cognitive function.
Several studies have shown that unlike the first generation of racetams
(piracetam, oxiracetam, and aniracetam), nefiracetam also has a positive
effect on mood, and acts as an antidepressent. It also stimulates the
AMPA receptors in the brain. Substances which affect the brains AMPA
receptors are known as Ampakines, and these substances have been shown
to greatly increase attention span, learning ability, altertness, and
general cognitive functions.
As with all of our racetams, nefiracetam is very popular among students,
sufferers of Alzheimer's and dementia, those recovering from
alcoholism, and life extension enthusiasts.
As with most all racetams, nefiracetam should be taken with a choline
source such as choline bitartrate. It is also often ‘stacked’ with other
racetams as well as with supplements such as GABA, and L-Tyrosine, and
L-Phenylananine.
9-Me-BC powder is a methylated derivative of β-carboline with the
molecular formula C12H10N2. It may be prepared by preforming the
Eschweiler–Clarke reaction on freebase β-carboline (norharmane).
beta carboline powder
In vitro studies with dopaminergic neuron cell cultures demonstrated
increased expression of tyrosine hydroxylase and associated
transcription factors, increased neurite outgrowth, regeneration of
neurons after chronic rotenone administration, and reduced expression of
inflammatory cytokines. In studies of primary mesencephalic
dopaminergic neuron cell cultures, the substance increased the number of
differentiated dopaminergic neurons and produced higher levels of
transcription factors associated with dopaminergic differentiation.[2]
9-Me-BC also inhibited the oxidation of the neurotoxin precursor MPTP to
the dopaminergic neurotoxin MPP+ in vitro.
Rodent studies in vivo demonstrated elevated hippocampal dopamine
levels, improved spatial learning performance in a radial maze test, and
increased dendrite outgrowth in the dentate gyrus of the hippocampus,
as well as restoration of the number of tyrosine hydroxylase expressing
neurons in the left striatum after an injection of MPP+ had reduced the
number of such cells by 50% in an animal model of Parkinsonism.
β-Carbolines (BCs) belong to the heterogenous family of carbolines,
which have been found exogenously, that is, in various fruits, meats,
tobacco smoke, alcohol and coffee, but also endogenously, that is,
blood, brain and CSF. These exogenous and endogenous BCs and some of
their metabolites can exert neurotoxic effects, however, an unexpected
stimulatory effect of 9-methyl-β-carboline (9-me-BC) on dopaminergic
neurons in primary mesencephalic cultures was recently discovered. The
aim of the present study was to extend our knowledge on the stimulatory
effects of 9-me-BC and to test the hypothesis that 9-me-BC may act as a
cognitive enhancer. We found that 10 days (but not 5 days) of
pharmacological treatment with 9-me-BC (i) improves spatial learning in
the radial maze, (ii) elevates dopamine levels in the hippocampal
formation, and (iii) results after 10 days of treatment in elongated,
more complex dendritic trees and higher spine numbers on granule neurons
in the dentate gyrus of 9-me-BC-treated rats. Our results demonstrate
that beyond its neuroprotective/neurorestorative and anti-inflammatory
effects, 9-me-BC acts as a cognitive enhancer in a hippocampus-dependent
task, and that the behavioral effects may be associated with a
stimulatory impact on hippocampal dopamine levels and dendritic and
synaptic proliferation.
We all at one point find ourselves working through the night shift,
beating strict deadlines, or even burning the midnight oil for the sake
of a test. So, what is the first thing that comes to your mind when
thinking about any of these tasks? I bet you thought about a cup of hot
concentrated coffee or some energizing drink.Well, nootropics are not
your typical cup of caffeine. They do more than stimulating your brain,
stirring up insomnia, and causing annoying jitters.
oxiracetam buy
A single dose is enough to increase your intellect, power up your
cranial capacity, and improve your learning ability. This fact seems too
good to be true, right? Hold your horses because there are several
successful clinical trials to it back up. After all, medical doctors
discovered the potency of racetams and gave it a go when managing
patients with dementia, ADHD, and Alzheimer’s.
Are you looking to go beyond your limits? Before you swallow this
limitless pill, let’s find out if the drug is worth it.Racetams are
synthetic compounds belonging to the Nootropic Family. The group
comprises of over 15 different chemicals. They all feature two
pyrrolidone nucleus with oxygen, hydrogen, and nitrogen molecules.
Although they share a chemical backbone, each racetam has a parallel
function. The differences in the structural orientation are responsible
for the dissimilarities in potency, mechanism of action, metabolism,
dosage, and half-life.
Racetams modulate the level of acetylcholine in the brain. The
neurotransmitter accounts for most of the cognitive functions, including
attentiveness, logical thinking, focus, concentration, and memory
formation.
History
Racetam is the forerunner of all the other nootropics. However, its
existence was coincidental.Dr. Corneliu Giurgea and his co-researchers
were designing a molecule that could reverse abnormal sleep pattern and
motion sickness.
However, by a twist of fate, these scientists discovered that the
compound could also enhance focus and heighten the mental state of the
user. Taking advantage of this side effect, Dr. Corneliu Giurgea and his
team set out to investigate the role of racetams in cognition and brain
functionalities.
Upon the successful discovery, piracetam became the godfather of the
racetam family. This invention occurred in 1964. Subsequently,
researchers saw the need to improve this generic smart drug and came up
with superior versions, including Oxiracetam nootropics.
Oxiracetam is one of the compounds found in the Racetam family, and is
one of the most well-established Nootropic compounds available.
Oxiracetam has shown the ability to benefit learning ability, retention
of memory, sociability, and also offers neuroprotective and
neuroregenerative benefits to those suffering from dementia 1.
Oxiracetam is a synthetic Nootropic that is not found naturally in
nature or food and is water soluble. A typical Oxiracetam dosage ranges
from 300-750mg, although there are many accounts of those taking doses
greater than 1g without unpleasant side effects.
oxiracetam
Benefits of Oxiracetam
Oxiracetam is thought to act on the acetylcholine and cholinergic
pathways of the brain. This provides a stimulating effect that isn’t
typically mood-affective like other racetams like Aniracetam. Oxiracetam
is currently considered a non-food, unapproved drug by the FDA and
therefore exists in a bit of a regulatory grey area. Oxiracetam has been
widely investigated for its application in the reduction of
dementia-related symptoms, as well as its ability to offer
neuroprotective action. Results vary, but Oxiracetam is generally
regarded as being able to offer much benefit to those suffering with
dementia, and typically over the age of 65. Clinical data regarding
Oxiracetam usage in humans is lacking to make any broad-sweeping claims
as to the benefit of this compound, but several animal studies have
shown highly–beneficial neuroregenerative action and neuroprotective
action seen with the administration of Oxiracetam 2.
Oxiracetam is regarded as offering the ability to greatly enhance the logical, decision–making capacity of the mind
Anecdotal evidence, much of which is taken from online accounts of
individual user experiences, illustrates a very exciting range of
potential benefits offered by Oxiracetam. Oxiracetam is regarded as
offering the ability to greatly enhance the logical, decision–making
capacity of the mind and many users describe a more ‘level-headed’
approach in decision making. Oxiracetam is regarded as being a
memory-enhancing compound, especially with regards to long-term memory
formation and the absorption of new information. Oxiracteam is also
known to increase attention span, improve the speed at which one is able
to process information, and generally improve the overall learning
ability of the user. For these reasons, Oxiracetam is often preferred by
many academic users in place of more extreme alternatives such as
Adderal, Vyvanse, and Ritalin.
Oxiracetam vs Aniracetam
Oxiracetam and Aniracetam are both known to exhibit stronger overall
effects than Piracetam, and are generally regarded as both being among
the most popular of all Racetam Nootropics. Oxiracetam is known to be
more stimulating than Aniracetam, and also less-affective towards mood
and emotions. Oxiracetam is generally taken by people who have issues
responding to Piracetam, or simply want more pronounced effects. The
experience of Oxiracetam is often summarized as a generalized
stimulation of mental energy, and is interpreted by many as having a
slightly anxious ‘edge’ in some cases. Aniracetam is a fat-soluble
compound and must be taken with fats, or with a meal, to be properly
absorbed by the body. Oxiracetam is water soluble and can easily be
administered between meals and is easily mixable in a glass of water.
Higher consumption of tomatoes could be associated with a decreased risk
of liver cancer caused by high-fat diets, a study has found.The study,
conducted on mice, showed that tomatoes are rich in lycopene -- a strong
antioxidant, anti-inflammatory and anti-cancer agent -- which helps in
effectively reducing fatty liver disease, inflammation and liver cancer
development.
Lycopene powder
"Consuming whole foods like tomatoes and processed tomatoes from sauces,
tomato paste, canned whole tomato products, ketchup and juice, provides
the best source of lycopene," said Xiang-Dong Wang, Professor at Tufts
University in the US.
Interestingly, we observed that tomato powder is more effective than the
same dose of purified lycopene supplementation to prevent liver cancer
development, said Wang.This could be due to the potential beneficial
effects of other nutrients in a whole tomato, such as vitamin E, vitamin
C, folate, minerals, phenolic compounds and dietary fibres.
In addition, feeding mice tomato powder increased the richness and
diversity of beneficial microbiota and prevented the over-growth of some
bacteria related to inflammation, said the study, published in the
journal Cancer Prevention Research.
For the study, infant mice were infected with a liver carcinogen and
then fed an unhealthy high-fat diet similar to a Western diet, with or
without tomato powder containing lycopene.Other foods including guava,
watermelon, grapefruit, papaya, and sweet red pepper also contain
lycopene, but in much lower concentrations compared to tomatoes.
Eating tomatoes and tomato products such as tomato sauce rich in
lycopene is also associated with a lower risk of cardiovascular disease,
osteoporosis, diabetes, and certain cancers, including prostate, lung,
breast and colon cancer, the study showed.
3-O-Ethyl-L-Ascorbic Acid, or Ethyl Ascorbic Acid is a molecule produced
by modifying Ascorbic Acid, commonly known as Vitamin C. This
modification is done to increase the molecule’s stability and enhance
its transport through skin, as pure Vitamin C is easily degraded. In the
body, the modifying group is removed and Vitamin C is restored in its
natural form. Thus, Ethyl Ascorbic Acid retains the benefits of Vitamin
C, such as antioxidant activity. Furthermore, it is even more potent in
reducing skin darkening after UV exposure. It even has some additional
effects, not observed in pure Ascorbic Acid, such as promoting nerve
cell growth or reducing chemotherapy damage. Finally, the slower release
also ensures that no toxic effects are observed when using this Vitamin
C derivative.
3-O-Ethyl-L-Ascorbic Acid
3-O-ethyl-L-ascorbic acid is an ethered derivative of ascorbic acid，the
most excellent derivative of ascorbic acid so far. It is very stable in
chemical structure, a real stable and discolored derivative of ascorbic
acid, but also it can enter into skin and be metabolized by body as
ascorbic acid. So its effect is better than pure ascorbic acid.
3-O-ethyl-L-ascorbic acid is a unique lipophilic and hydrophilic
material, easily used in cosmetic formulation. The most important is
that 3-O-ethyl-L-ascorbic acid can easily enter into dermis and play
biological effect, while pure ascorbic acid almost does not enter into
dermis. 3-O-ethyl ascorbic acid is an excellent choice for cosmetic
chemists.
l-ascorbic acid (AA), commonly known as vitamin C, has been widely used
in topical formulations for many years as an antioxidant and anti-aging
ingredient. However, the physicochemical properties of AA are not
optimal for skin uptake and the molecule is also unstable, readily
undergoing oxidation on exposure to air. The compound
3-o-ethyl-l-ascorbic acid (EA) has been developed as a stable vitamin C
derivative and has been used in topical products.
Global Market Insights, Inc. has announced the launch of ethyl ascorbic
acid market, a comprehensive study enumerating the latest price trends
and pivotal drivers rendering a positive impact on the industry
landscape. Further, the report is inclusive of the competitive terrain
of this vertical in addition to the market share analysis and the
contribution of the prominent contenders toward the overall industry.
86404-04-8
Ethyl Ascorbic Acid Market size is mainly driven by growing concern
about physical appearance coupled with development of skincare. Ethyl
ascorbic acid or 3-O-ethyl-L-ascorbic acid is a stable derivative of
ascorbic acid. It offers the benefits of vitamin C to the skin and helps
in reducing skin darkening caused by excessive exposure to ultraviolet
rays. Owing to anti-tanning properties, it also finds applications in
sunscreen products.
The organic skin care market is expected to grow at a CAGR of over 18%
over the forecast timeframe. Inclination towards organic products in
European countries is expected to fuel ethyl ascorbic acid market
growth. Additionally, growth in the consumption of skincare products in
countries, like Germany, France, and the UK, is expected to further
escalate the Europe ethyl ascorbic acid industry.
The structure of the acid is relatively stable when compared to vitamin C
as ethyl group forms an ether with the 3-hydroxy(OH) group of ascorbic
acids. Other derivatives of ascorbic acid, such as ethers at
2-hydroxy(OH) place, can be commercialized. It enhances the skin tone
and has a whitening effect; hence, it is used as an active ingredient in
skin whitening products. A rise in demand for cosmetic products will
drive the ethyl ascorbic acid market demand.
X
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The global skin care market size was estimated to be USD 115 billion in
2015 and will be worth about USD 190 billion by 2024. An increase in
spending power coupled with awareness about the skin care products in
Asian nations will enhance ethyl ascorbic acid market demand.
Consumption growth of personal care products with increasing
applications will drive ethyl ascorbic acid market growth. The product
is more beneficial than the natural vitamin C and excessive application
does not cause harm to the skin. Its content in personal care products
ranges between 0.5% to 10%.Growth in the consumption of skin whitening
products is trending in Asian countries such as India and China. The
skin care industry in India is expected to grow at a CAGR 30% by 2024
owing to the desire for fair skin. Growth in domestic skin care and
cosmetic industries will further drive ethyl ascorbic acid market
growth.
Topical application of the product may cause side effects on the skin,
such as peeling, loosening, and allergy, due to forceful rubbing of the
product leading to lymph secretion in the upper layer of the skin. This
may act as a challenge to the market growth. Also, the presence of
imitation products may act as a restraint to ethyl ascorbic acid market
growth.
Some of the key industry players of ethyl ascorbic acid market are
Yantai Aurora Chemical Co., Ltd., Parchem Fine & Specialty
Chemicals, Vantage Specialty Ingredients, Gfn-Selco, BulkActives, DSM
Nutritional Products AG, M.C.Biotec, Inc., GREAF, Gonmisol, Rhino
Linings Corporation, and Nippon Fine Chemicals.
MALE ESTROGEN BLOCKER - When a man’s body has excess estrogen, men can
experience many unfavorable, embarrassing side effects. Chrysin is a
aromatase inhibitor that helps prevent the conversion of testosterone to
estrogen allowing your testosterone levels to increase.
Chrysin powder
LOW TESTOSTERONE? - If you are feeling the effects of low testosterone
(low sex drive, fatigue, hair loss and more), there is a possibility
that aromatase could be the culprit. Chrysin cream can help inhibit
aromatase from converting your testosterone into estrogen. Blocking
aromatase activity can provide a natural youthful boost to your
testosterone level and an overall improvement in your well being.
CHRYSIN CREAM IS MUCH MORE EFFECTIVE - Estrogen Block cream more
effectively delivers chrysin’s aromatase inhibiting benefits to your
body than pills, capsules and powders to. Creams bypass the stomach and
liver minimising gastric degradation and first pass metabolism. Much
smaller amounts of chrysin are needed to provide better estrogen
blocking results.
HOW TO USE ESTROGEN BLOCK - Apply 1/4 teaspoon (2 pumps) of Estrogen
Block cream daily for the first 2 weeks (50 mg Chrysin daily); then
apply 1/2 teaspoon (4 pumps) of cream daily (100 mg Chrysin daily) .
Maximum suggested dose is 1 teaspoon (8 pumps) which equals about 200 mg
daily dose. Once you have used the chrysin cream for 2 months or so,
you should go for a hormone test to evaluate your estrogen /
testosterone levels and if there is no change then you can increase the
dose.
Men can experience estrogen dominance when excess aromatase enzyme
activity occurs. Chrysin (Passion Flower Extract) can be extremely
beneficial to men who are looking to regulate the testosterone /
estrogen balance in their body and recapture the “vigor” of their youth.
The use of this extract can result in the following positive effects in
male patients:
Balance Estradiol / Estrogen
Boost Testosterone
Greater stamina
Increased mental clarity
Higher energy levels
Increased libido
Greater muscle tone
Greater mood
GHS H Statement:
Causes serious eye damage.
Harmful if swallowed.
Causes severe skin burns and eye damage.
GHS P Statement:
IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
Wear eye protection/face protection.
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Immediately call a POISON CENTER or doctor/physician.
N-Phenyl-N-(4-piperidinyl)propanamide HCL powder
IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
WARNING: The information provided on this web site was developed in
compliance with European Union (EU) regulations and is correct to the
best of our knowledge, information and belief at the date of its
publication. The information given is designed only as a guide for safe
handling and use. It is not to be considered as either a warranty or
quality specification.
