Which populations should avoid using Tazzle? | Forum

Tazzle, which contains the active ingredient tadalafil, is a medication primarily used to treat erectile dysfunction (ED) in men. While tadalafil is generally safe and effective for most individuals, there are certain populations who should avoid using Tazzle or use it with caution under medical supervision. Here are some populations who should exercise caution or avoid using Tazzle altogether: Individuals with Cardiovascular Disease: Tadalafil, the active ingredient in Tazzle, can lower blood pressure. Therefore, individuals with cardiovascular disease, including those with a history of heart attack, stroke, or life-threatening arrhythmia, should use Tazzle with caution and under the guidance of a healthcare provider. Those Taking Nitrates: Tadalafil can potentiate the hypotensive (blood pressure-lowering) effects of nitrates, such as nitroglycerin, used to treat angina (chest pain) and other cardiovascular conditions. Concurrent use of Tazzle with nitrates is contraindicated due to the risk of severe hypotension, which can be life-threatening. Individuals with Severe Liver or Kidney Disease: Tadalafil is primarily metabolized in the liver and excreted by the kidneys. Therefore, individuals with severe liver or kidney disease may have impaired drug metabolism and clearance, leading to an increased risk of adverse effects. Tazzle should be used with caution or avoided in these populations. Men with Hereditary Retinal Disorders: Tadalafil has been associated with rare cases of non-arteritic anterior ischemic optic neuropathy (NAION), a condition that can lead to sudden vision loss. While the causal relationship between tadalafil and NAION is unclear, men with hereditary retinal disorders or a history of NAION should use Tazzle with caution and under medical supervision. Individuals with Penile Implants or Severe Penile Deformities: Tazzle is not intended for use in individuals with penile implants or severe penile deformities, as its safety and effectiveness in these populations have not been established. Women and Children: Tazzle is intended for use by adult men only and should not be used by women or children. It's important for individuals considering the use of Tazzle to discuss their medical history and any underlying health conditions with a healthcare provider before starting treatment. Your healthcare provider can assess the potential risks and benefits of using Tazzle and provide personalized advice based on your individual health status and needs.